Breast Milk Jaundice and Maternal Diet with Chinese Herbal Medicines

Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 150120, 6 pages

Yi-HaoWeng,1 Ya-Wen Chiu,2, 3 and Shao-Wen Cheng1


Our objective was to identify the association between maternal diet with Chinese herbal medicines and prolonged jaundice of breast-fed infants. Healthy infants at 25 to 45 days of age were eligible for enrollment into this prospective study. Jaundice was defined as a transcutaneous bilirubin (TcB) value ≥ 5mg/dL. A questionnaire survey asking feeding type, stool pattern, and maternal diet was conducted at the time of TcB measurement. A total of 1148 infants were enrolled, including 151 formula-fed, 436 combination-fed, and 561 breast-fed infants. The incidences of jaundice were 4.0% in formula-fed infants, 15.1% in combinationfed infants, and 39.8% in breast-fed infants (P < 0.001). In addition, jaundice was noted in 37.1% of preterm infants and 25.0% of term infants (P < 0.001). Furthermore, jaundice was more common in breast-fed infants whose mothers did not consume the traditional Chinese herbal medicines than in breast-fed infants whose mothers did consume such medicines (P < 0.001). 


In conclusion, this cohort study has identified late-preterm birth and breast feeding as the contributory factors for prolonged jaundice of apparently well infants. The data indicate that postpartum diet with Chinese herbal medicines is associated with breast milk jaundice.

late-preterm infant & breast-feeding 군일수록 황달 유병율 높음.

 

완전모유수유군의 상대위험도 19.881, 혼합수유군 4.539, 조산군 1.998 순으로 나타남. 

한약 복용군에서 황달 유병율의 유의성 있는 감소 및 대변 횟수의 적정성을 보이고 있음.

(후기)모유 황달과 관련하여 요인을 분석한 논문.
조산, 완전 모유수유아들에게 황달 비율이 높음.
한약 복용군(생화탕, 사물탕, 두충. 기타 한약은 조사되지 않음.)의 infant에서 황달 비율이 유의성있게 낮음.

1. 모체의 식이 상태에 따라 모유 성분의 변화가 있다.
   (changes in maternal diet can affect the composition of breast milk)
2. 성분이 확인되지 않았지만, 한약 복용은 모체와 신생아에게 모두 도움이 될 수 있다. 
   (our results indicate that a combination of chinese medicines with a traditional chinese maternal diet may decrease the development of prolonged jaundice.)
3. 산모가 감초를 복용함으로써 빌리루빈 청소율을 높인다는 보고.
(Traditional Chinese medicine and treatment of neonatal jaundice, 1996 -> 인진, 대황, 감초, 황금, 황련)
(Neonatal jaundice--traditional Chinese medicine approach, 2001 -> 비슷한 내용)
4. 모유는 빌리루빈의 재흡수를 촉진하며, 장간순환하는 빌리루빈 양이 증가하면서 황달이 연장됨.
(Enterohepatic circulation of nonconjugated bilirubin in rats fed with human milk, 1990)