Abstract
Background
Isoflavone compounds naturally occurring in the root of the kudzu plant have been used historically to treat alcohol-related problems. A pilot study was conducted to assess the effects of one primary isoflavone –puerarin – for its ability to modify alcohol intake in humans.
Methods
Ten (10) healthy adult volunteers were administered puerarin (1200 mg daily) in a double-blind, placebo-controlled, crossover design experiment for one week prior to an afternoon drinking session lasting 1.5 h. Participants had access to up to six bottles of their preferred brand of beer in addition to juice and water. A time course of drinking, sip volumes, and total amount consumed were recorded.
Results
Participants consumed on average 3.5 (±0.55) beers when treated with placebo and 2.4 (±0.41) beers when treated with puerarin. In contrast to drinking following placebo treatment when 3 participants drank 5 beers and 1 participant drank all 6 beers, none drank 5 or 6 beers when treated with puerarin. Drinking topography also changed. When treated with puerarin, participants decreased sip size, took more sips to finish a beer, and took longer to consume each beer. Additionally, after finishing a beer, latency to opening the next beer was increased.
Conclusions
This study is the first demonstration that a single isoflavone found in the kudzu root can alter alcohol drinking in humans. These results suggest that alcohol consumption patterns are influenced by puerarinadministration and this botanical medication may be a useful adjunct in the treatment of excessive alcohol intake.
갈근의 puerarin 함량을 평균 3%로 계산했을 때, 하루 1200mg 사용한 이 실험에서 요구되는 갈근 약재는 40g/day.
즉, 2첩 10돈이다. 물론 메탄올 75% 추출시 적용되는 이야기이나, 어떤 보고에서는 물추출과 메탄올 추출이 거의 비슷하다는 보고가 있다.
puerarin은 알코올 자체에 대한 주관적인 부정적 느낌을 강조하는 것이 아닌 간에서 mitochondrial ALDH2 pathway와 MAO-ALDH2 pathway를 조절하는 것으로 보고(동물실험 결과)되었다.
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